25-hydroxy Vitamin D3

25-hydroxy Vitamin D3 (25(OH)D3) is the primary circulating form of vitamin D in the human body and the most accurate marker for assessing vitamin D status. It is synthesized in the skin upon exposure to UVB radiation from sunlight and can also be obtained from dietary sources such as fatty fish, egg yolks, and fortified foods. Once produced or ingested, vitamin D3 is converted in the liver to 25(OH)D3, which is the major storage form of vitamin D. This form is essential for maintaining calcium and phosphate balance, supporting bone health, and modulating immune, endocrine, and neuromuscular functions.

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Why is 25-hydroxy Vitamin D3 regarded as the most reliable indicator of vitamin D status?

Because it reflects both natural production from sunlight and intake from food or supplements, 25(OH)D3 provides a comprehensive view of the body’s vitamin D levels.

What are the consequences of low 25(OH)D3 levels?

Low levels may be linked to bone loss, a higher risk of fractures, muscle weakness, fatigue, and a weakened immune system.

Is 25(OH)D3 more effective than 25(OH)D2?

Yes, Vitamin D3 is generally more effective than D2 at increasing and maintaining overall vitamin D levels due to its longer half-life and higher binding affinity in the body.

Content
Why is 25-hydroxy Vitamin D3 regarded as the most reliable indicator of vitamin D status?
What are the consequences of low 25(OH)D3 levels?
Is 25(OH)D3 more effective than 25(OH)D2?
Why is 25-hydroxy Vitamin D3 regarded as the most reliable indicator of vitamin D status?
What are the consequences of low 25(OH)D3 levels?
Is 25(OH)D3 more effective than 25(OH)D2?
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